1yc4

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[[Image:1yc4.png|left|200px]]
 
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{{STRUCTURE_1yc4| PDB=1yc4 | SCENE= }}
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==Crystal structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles==
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<StructureSection load='1yc4' size='340' side='right'caption='[[1yc4]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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===Crystal structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yc4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YC4 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15713410}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=43P:4-(1H-IMIDAZOL-4-YL)-3-(5-ETHYL-2,4-DIHYDROXY-PHENYL)-1H-PYRAZOLE'>43P</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yc4 OCA], [https://pdbe.org/1yc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yc4 RCSB], [https://www.ebi.ac.uk/pdbsum/1yc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yc4 ProSAT]</span></td></tr>
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[[1yc4]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YC4 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yc/1yc4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yc4 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Heat Shock Proteins|Heat Shock Proteins]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015713410</ref><ref group="xtra">PMID:017257425</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Brinker, A.]]
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[[Category: Large Structures]]
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[[Category: Caldwell, J.]]
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[[Category: Brinker A]]
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[[Category: Choi, H.]]
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[[Category: Caldwell J]]
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[[Category: Gu, X.]]
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[[Category: Choi H]]
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[[Category: Han, S.]]
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[[Category: Gu X]]
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[[Category: He, Y.]]
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[[Category: Han S]]
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[[Category: Kreusch, A.]]
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[[Category: He Y]]
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[[Category: Lesley, S A.]]
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[[Category: Kreusch A]]
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[[Category: Zhou, V.]]
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[[Category: Lesley SA]]
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[[Category: Cancer]]
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[[Category: Zhou V]]
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[[Category: Cell cycle]]
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[[Category: Cell-cycle]]
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[[Category: Drug design]]
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Current revision

Crystal structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles

PDB ID 1yc4

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