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2hfw

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[[Image:2hfw.png|left|200px]]
 
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{{STRUCTURE_2hfw| PDB=2hfw | SCENE= }}
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==Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III==
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<StructureSection load='2hfw' size='340' side='right'caption='[[2hfw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2hfw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HFW FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17427958}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfw OCA], [https://pdbe.org/2hfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hfw RCSB], [https://www.ebi.ac.uk/pdbsum/2hfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hfw ProSAT]</span></td></tr>
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[[2hfw]] is a 1 chain structure of [[Carbonic anhydrase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFW OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAH3_HUMAN CAH3_HUMAN] Reversible hydration of carbon dioxide.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/2hfw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hfw ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Carbonic anhydrase|Carbonic anhydrase]]
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*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017427958</ref><references group="xtra"/>
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[[Category: Carbonate dehydratase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Elder, I.]]
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[[Category: Large Structures]]
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[[Category: Fisher, S Z.]]
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[[Category: Elder I]]
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[[Category: Laipis, P J.]]
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[[Category: Fisher SZ]]
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[[Category: McKenna, R.]]
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[[Category: Laipis PJ]]
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[[Category: Silverman, D N.]]
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[[Category: McKenna R]]
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[[Category: Tu, C K.]]
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[[Category: Silverman DN]]
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[[Category: Hca iii]]
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[[Category: Tu CK]]
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[[Category: Lyase]]
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[[Category: Proton shuttle]]
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[[Category: Proton transfer]]
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Current revision

Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III

PDB ID 2hfw

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