1s69

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[[Image:1s69.png|left|200px]]
 
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{{STRUCTURE_1s69| PDB=1s69 | SCENE= }}
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==The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with cyanide ligand==
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<StructureSection load='1s69' size='340' side='right'caption='[[1s69]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S69 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s69 OCA], [https://pdbe.org/1s69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s69 RCSB], [https://www.ebi.ac.uk/pdbsum/1s69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s69 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRHBN_SYNY3 TRHBN_SYNY3] Forms a very stable complex with oxygen. The oxygen dissociation rate is 0.011 s(-1).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s6/1s69_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s69 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structures of cyanide and azide-bound forms of the truncated hemoglobin from Synechocystis are presented at 1.8 angstroms resolution. A comparison with the structure of the endogenously liganded protein reveals a conformational shift unprecedented in hemoglobins, and provides the first picture of a hexacoordinate hemoglobin in both the bis-histidyl and the exogenously coordinated states. The structural changes between the different conformations are confined to two regions of the protein; the B helix, and the E helix, including the EF loop. A molecular "hinge" controlling movement of the E helix is observed in the EF loop, which is composed of three principal structural elements: Arg64, the heme-d-propionate, and a three-residue extension of the F helix. Additional features of the structural transition between the two protein conformations are discussed as they relate to the complex ligand-binding behavior observed in hexacoordinate hemoglobins, and the potential physiological function of this class of proteins.
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===The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with cyanide ligand===
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Crystallographic analysis of synechocystis cyanoglobin reveals the structural changes accompanying ligand binding in a hexacoordinate hemoglobin.,Trent JT 3rd, Kundu S, Hoy JA, Hargrove MS J Mol Biol. 2004 Aug 20;341(4):1097-108. PMID:15289104<ref>PMID:15289104</ref>
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{{ABSTRACT_PUBMED_15289104}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1s69" style="background-color:#fffaf0;"></div>
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[[1s69]] is a 1 chain structure of [[Hemoglobin]] with sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S69 OCA].
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==See Also==
==See Also==
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*[[Hemoglobin|Hemoglobin]]
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015289104</ref><references group="xtra"/>
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__TOC__
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[[Category: Synechocystis sp.]]
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</StructureSection>
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[[Category: Hargrove, M S.]]
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[[Category: Large Structures]]
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[[Category: Hoy, J A.]]
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[[Category: Synechocystis sp. PCC 6803]]
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[[Category: III, J T.Trent.]]
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[[Category: Hargrove MS]]
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[[Category: Kundu, S.]]
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[[Category: Hoy JA]]
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[[Category: 2 on 2 helical fold]]
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[[Category: Kundu S]]
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[[Category: Cyanobacteria]]
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[[Category: Trent III JT]]
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[[Category: Globin]]
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[[Category: Heme]]
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[[Category: Hemoglobin]]
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[[Category: Hexacoordinate]]
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[[Category: Iron]]
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[[Category: Oxygen binding]]
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[[Category: Oxygen storage-transport complex]]
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[[Category: Truncated]]
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Current revision

The X-ray structure of the cyanobacteria Synechocystis hemoglobin "cyanoglobin" with cyanide ligand

PDB ID 1s69

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