1f9u

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[[Image:1f9u.png|left|200px]]
 
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{{STRUCTURE_1f9u| PDB=1f9u | SCENE= }}
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==CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE==
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<StructureSection load='1f9u' size='340' side='right'caption='[[1f9u]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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===CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1f9u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F9U FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11387196}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f9u OCA], [https://pdbe.org/1f9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f9u RCSB], [https://www.ebi.ac.uk/pdbsum/1f9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f9u ProSAT]</span></td></tr>
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[[1f9u]] is a 1 chain structure of [[Kinesin]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F9U OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAR3_YEAST KAR3_YEAST] Essential for yeast nuclear fusion during mating. KAR3 is a bifunctional protein having a kinesin-like motor domain joined to a distinct microtubule binding domain. It may mediate microtubule sliding during nuclear fusion and possibly mitosis. May interact with spindle microtubules to produce an inwardly directed force acting upon the poles. KAR3 function antagonizes CIP8 and KIP1 outward force action. KAR3 motor activity is directed toward the microtubule's minus end.<ref>PMID:2138512</ref> <ref>PMID:11729143</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/1f9u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f9u ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Kinesin|Kinesin]]
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011387196</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Endow, S A]]
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[[Category: Endow SA]]
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[[Category: Park, C G.]]
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[[Category: Park CG]]
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[[Category: Park, H W.]]
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[[Category: Park HW]]
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[[Category: Yun, M.]]
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[[Category: Yun M]]
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[[Category: Zhang, X.]]
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[[Category: Zhang X]]
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[[Category: Contractile protein]]
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[[Category: Kar3]]
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[[Category: Kinesin-related protein]]
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[[Category: Microtubule binding protein]]
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[[Category: Motor protein]]
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Current revision

CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE

PDB ID 1f9u

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