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1mep

From Proteopedia

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[[Image:1mep.png|left|200px]]
 
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{{STRUCTURE_1mep| PDB=1mep | SCENE= }}
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==Crystal Structure of Streptavidin Double Mutant S45A/D128A with Biotin: Cooperative Hydrogen-Bond Interactions in the Streptavidin-Biotin System.==
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<StructureSection load='1mep' size='340' side='right'caption='[[1mep]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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===Crystal Structure of Streptavidin Double Mutant S45A/D128A with Biotin: Cooperative Hydrogen-Bond Interactions in the Streptavidin-Biotin System.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mep]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MEP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16452627}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mep OCA], [https://pdbe.org/1mep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mep RCSB], [https://www.ebi.ac.uk/pdbsum/1mep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mep ProSAT]</span></td></tr>
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[[1mep]] is a 4 chain structure of [[Avidin]] with sequence from [http://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEP OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/1mep_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mep ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Avidin|Avidin]]
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*[[Avidin 3D structures|Avidin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:016452627</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Streptomyces avidinii]]
[[Category: Streptomyces avidinii]]
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[[Category: Green, N M.]]
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[[Category: Green NM]]
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[[Category: Hyre, D E.]]
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[[Category: Hyre DE]]
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[[Category: Merritt, E A.]]
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[[Category: Le Trong I]]
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[[Category: Stayton, P S.]]
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[[Category: Merritt EA]]
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[[Category: Stenkamp, R E.]]
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[[Category: Stayton PS]]
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[[Category: Trong, I Le.]]
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[[Category: Stenkamp RE]]
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[[Category: Biotin-binding protein]]
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[[Category: Homotetramer]]
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Current revision

Crystal Structure of Streptavidin Double Mutant S45A/D128A with Biotin: Cooperative Hydrogen-Bond Interactions in the Streptavidin-Biotin System.

PDB ID 1mep

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