1t4w

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[[Image:1t4w.png|left|200px]]
 
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{{STRUCTURE_1t4w| PDB=1t4w | SCENE= }}
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==Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1==
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<StructureSection load='1t4w' size='340' side='right'caption='[[1t4w]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1t4w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T4W FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15242600}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4w OCA], [https://pdbe.org/1t4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t4w RCSB], [https://www.ebi.ac.uk/pdbsum/1t4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4w ProSAT]</span></td></tr>
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[[1t4w]] is a 1 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4W OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CEP1_CAEEL CEP1_CAEEL] Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. However, not required for DNA repair in response to UV-C or to regulate cell-cycle progression. Required for induction of ced-13 in response to DNA damage. Regulates germline proliferation by activating phg-1.<ref>PMID:11696333</ref> <ref>PMID:11557844</ref> <ref>PMID:12445383</ref> <ref>PMID:15273685</ref> <ref>PMID:15707894</ref> <ref>PMID:15605074</ref> <ref>PMID:16319925</ref> <ref>PMID:17276923</ref> <ref>PMID:17186023</ref> <ref>PMID:17347667</ref> <ref>PMID:17895432</ref> <ref>PMID:18627611</ref> <ref>PMID:18836529</ref> <ref>PMID:19015549</ref>
==See Also==
==See Also==
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*[[P53|P53]]
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*[[P53 3D structures|P53 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015242600</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Derry, W B.]]
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[[Category: Large Structures]]
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[[Category: Halazonetis, T D.]]
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[[Category: Derry WB]]
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[[Category: Huyen, Y.]]
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[[Category: Halazonetis TD]]
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[[Category: Jeffrey, P D.]]
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[[Category: Huyen Y]]
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[[Category: Pavletich, N P.]]
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[[Category: Jeffrey PD]]
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[[Category: Rothman, J H.]]
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[[Category: Pavletich NP]]
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[[Category: Stavridi, E S.]]
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[[Category: Rothman JH]]
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[[Category: Dna-binding domain]]
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[[Category: Stavridi ES]]
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[[Category: Transcription]]
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Current revision

Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1

PDB ID 1t4w

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