1osz

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[[Image:1osz.png|left|200px]]
 
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{{STRUCTURE_1osz| PDB=1osz | SCENE= }}
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==MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND AN (L4V) MUTANT OF THE VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN==
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<StructureSection load='1osz' size='340' side='right'caption='[[1osz]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1osz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osz OCA], [https://pdbe.org/1osz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osz RCSB], [https://www.ebi.ac.uk/pdbsum/1osz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1osz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1osz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The T lineage repertoire is shaped by T cell receptor (TCR)-dependent positive and negative thymic selection processes. Using TCR-transgenic (N15tg) beta2-microglobulin-deficient (beta2m-/-) RAG-2(-/-) H-2(b) mice specific for the VSV8 (RGYVYQGL) octapeptide bound to Kb, we identified a single weak agonist peptide variant V4L (L4) inducing phenotypic and functional T cell maturation. The cognate VSV8 peptide, in contrast, triggers negative selection. The crystal structure of L4/Kb was determined and refined to 2.1 A for comparison with the VSV8/Kb structure at similar resolution. Aside from changes on the p4 side chain of L4 and the resulting alteration of the exposed Kb Lys-66 side chain, these two structures are essentially identical. Hence, a given TCR recognizes subtle distinctions between highly related ligands, resulting in dramatically different selection outcomes. Based on these finding and the recent structural elucidation of the N15-VSV8/Kb complex, moreover, it appears that the germ-line Valpha repertoire contributes in a significant way to positive selection.
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===MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND AN (L4V) MUTANT OF THE VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN===
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Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands.,Ghendler Y, Teng MK, Liu JH, Witte T, Liu J, Kim KS, Kern P, Chang HC, Wang JH, Reinherz EL Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10061-6. PMID:9707600<ref>PMID:9707600</ref>
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{{ABSTRACT_PUBMED_9707600}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1osz" style="background-color:#fffaf0;"></div>
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[[1osz]] is a 3 chain structure of [[Beta-2 microglobulin]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSZ OCA].
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==See Also==
==See Also==
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*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009707600</ref><ref group="xtra">PMID:010422827</ref><ref group="xtra">PMID:012479822</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Chang, H C.]]
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[[Category: Chang H-C]]
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[[Category: Ghendler, Y.]]
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[[Category: Ghendler Y]]
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[[Category: Kern, P.]]
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[[Category: Kern P]]
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[[Category: Kim, K S.]]
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[[Category: Kim KS]]
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[[Category: Liu, J.]]
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[[Category: Liu J]]
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[[Category: Liu, J H.]]
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[[Category: Liu J-H]]
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[[Category: Reinherz, E L.]]
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[[Category: Reinherz EL]]
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[[Category: Teng, M K.]]
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[[Category: Teng M-K]]
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[[Category: Wang, J H.]]
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[[Category: Wang J-H]]
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[[Category: Witte, T.]]
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[[Category: Witte T]]
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[[Category: Mhc-peptide complex]]
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[[Category: Thymic selection]]
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[[Category: Transmembrane protein]]
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Current revision

MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND AN (L4V) MUTANT OF THE VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN

PDB ID 1osz

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