1m4c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:31, 10 April 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1m4c.png|left|200px]]
 
-
{{STRUCTURE_1m4c| PDB=1m4c | SCENE= }}
+
==Crystal Structure of Human Interleukin-2==
-
 
+
<StructureSection load='1m4c' size='340' side='right'caption='[[1m4c]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
===Crystal Structure of Human Interleukin-2===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1m4c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4C FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_12582206}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4c OCA], [https://pdbe.org/1m4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4c RCSB], [https://www.ebi.ac.uk/pdbsum/1m4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4c ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[1m4c]] is a 2 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4C OCA].
+
== Disease ==
 +
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4c_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4c ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Interleukin|Interleukin]]
+
*[[Interleukin 3D structures|Interleukin 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:012582206</ref><ref group="xtra">PMID:012767230</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arkin, M A.]]
+
[[Category: Large Structures]]
-
[[Category: Braisted, A C.]]
+
[[Category: Arkin MA]]
-
[[Category: DeLano, W L.]]
+
[[Category: Braisted AC]]
-
[[Category: Hyde, J.]]
+
[[Category: DeLano WL]]
-
[[Category: Luong, T N.]]
+
[[Category: Hyde J]]
-
[[Category: McDowell, R S.]]
+
[[Category: Luong TN]]
-
[[Category: Oslob, J D.]]
+
[[Category: McDowell RS]]
-
[[Category: Randal, M.]]
+
[[Category: Oslob JD]]
-
[[Category: Raphael, D R.]]
+
[[Category: Randal M]]
-
[[Category: Taylor, L.]]
+
[[Category: Raphael DR]]
-
[[Category: Wang, J.]]
+
[[Category: Taylor L]]
-
[[Category: Wells, J A.]]
+
[[Category: Wang J]]
-
[[Category: Cytokine]]
+
[[Category: Wells JA]]
-
[[Category: Four-helix bundle]]
+

Current revision

Crystal Structure of Human Interleukin-2

PDB ID 1m4c

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m4c"
Personal tools