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1af3
From Proteopedia
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| - | [[Image:1af3.png|left|200px]] | ||
| - | + | ==RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN== | |
| - | + | <StructureSection load='1af3' size='340' side='right'caption='[[1af3]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1af3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AF3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1af3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1af3 OCA], [https://pdbe.org/1af3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1af3 RCSB], [https://www.ebi.ac.uk/pdbsum/1af3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1af3 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1af3]] is a 1 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/B2CL1_RAT B2CL1_RAT] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:8662675</ref> <ref>PMID:7828536</ref> <ref>PMID:18250306</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/1af3_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1af3 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Aritomi | + | [[Category: Aritomi M]] |
| - | [[Category: Inohara | + | [[Category: Inohara N]] |
| - | [[Category: Ishibashi | + | [[Category: Ishibashi Y]] |
| - | [[Category: Kunishima | + | [[Category: Kunishima N]] |
| - | [[Category: Morikawa | + | [[Category: Morikawa K]] |
| - | [[Category: Ohta | + | [[Category: Ohta S]] |
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Current revision
RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN
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