3bjy

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[[Image:3bjy.png|left|200px]]
 
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{{STRUCTURE_3bjy| PDB=3bjy | SCENE= }}
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==Catalytic core of Rev1 in complex with DNA (modified template guanine) and incoming nucleotide==
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<StructureSection load='3bjy' size='340' side='right'caption='[[3bjy]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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===Catalytic core of Rev1 in complex with DNA (modified template guanine) and incoming nucleotide===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bjy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BJY FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18275815}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCP:2-DEOXYCYTIDINE-5-TRIPHOSPHATE'>DCP</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P:2-DEOXY-N1,N2-PROPANO+GUANOSINE+MONOPHOSPHATE'>P</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjy OCA], [https://pdbe.org/3bjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bjy RCSB], [https://www.ebi.ac.uk/pdbsum/3bjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bjy ProSAT]</span></td></tr>
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[[3bjy]] is a 3 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJY OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/REV1_YEAST REV1_YEAST] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.<ref>PMID:8751446</ref> <ref>PMID:11316789</ref> <ref>PMID:16452144</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/3bjy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bjy ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018275815</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Aggarwal, A K.]]
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[[Category: Aggarwal AK]]
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[[Category: Johnson, R E.]]
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[[Category: Johnson RE]]
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[[Category: Nair, D T.]]
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[[Category: Nair DT]]
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[[Category: Prakash, L.]]
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[[Category: Prakash L]]
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[[Category: Prakash, S.]]
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[[Category: Prakash S]]
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[[Category: Adduct]]
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[[Category: Bypass]]
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[[Category: Dna damage]]
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[[Category: Dna polymerase]]
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[[Category: Dna repair]]
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[[Category: Dna synthesis]]
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[[Category: Dna-binding]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Nucleus]]
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[[Category: Protein-dna complex]]
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[[Category: Transferase]]
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[[Category: Transferase-dna complex]]
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Current revision

Catalytic core of Rev1 in complex with DNA (modified template guanine) and incoming nucleotide

PDB ID 3bjy

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