1gwy

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[[Image:1gwy.jpg|left|200px]]<br /><applet load="1gwy" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1gwy, resolution 1.71&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE WATER-SOLUBLE STATE OF THE PORE-FORMING CYTOLYSIN STICHOLYSIN II'''<br />
 
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==About this Structure==
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==Crystal structure of the water-soluble state of the pore-forming cytolysin Sticholysin II==
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1GWY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWY OCA].
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<StructureSection load='1gwy' size='340' side='right'caption='[[1gwy]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
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[[Category: Single protein]]
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== Structural highlights ==
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[[Category: Stichodactyla helianthus]]
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<table><tr><td colspan='2'>[[1gwy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GWY FirstGlance]. <br>
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[[Category: Gavilanes, J G.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
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[[Category: Hermoso, J A.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Mancheno, J M.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwy OCA], [https://pdbe.org/1gwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gwy RCSB], [https://www.ebi.ac.uk/pdbsum/1gwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwy ProSAT]</span></td></tr>
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[[Category: Martin-Benito, J.]]
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</table>
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[[Category: Martinez-Ripoll, M.]]
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== Function ==
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[[Category: SO4]]
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[https://www.uniprot.org/uniprot/ACTP2_STIHL ACTP2_STIHL] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers. Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts. Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects.<ref>PMID:10978735</ref> <ref>PMID:11478962</ref>
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[[Category: cnidocyst]]
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== Evolutionary Conservation ==
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[[Category: cytolysin]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: hemolysis]]
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Check<jmol>
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[[Category: pore-forming toxin]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/1gwy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gwy ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:54:51 2008''
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==See Also==
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*[[Cytolysin 3D structures|Cytolysin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Stichodactyla helianthus]]
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[[Category: Gavilanes JG]]
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[[Category: Hermoso JA]]
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[[Category: Mancheno JM]]
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[[Category: Martin-Benito J]]
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[[Category: Martinez-Ripoll M]]

Current revision

Crystal structure of the water-soluble state of the pore-forming cytolysin Sticholysin II

PDB ID 1gwy

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