1ecy

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[[Image:1ecy.png|left|200px]]
 
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{{STRUCTURE_1ecy| PDB=1ecy | SCENE= }}
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==PROTEASE INHIBITOR ECOTIN==
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<StructureSection load='1ecy' size='340' side='right'caption='[[1ecy]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ecy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ECY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ECY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900006:trehalose'>PRD_900006</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ecy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ecy OCA], [https://pdbe.org/1ecy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ecy RCSB], [https://www.ebi.ac.uk/pdbsum/1ecy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ecy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ECOT_ECOLI ECOT_ECOLI] General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity.[HAMAP-Rule:MF_00706]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/1ecy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ecy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ecotin, a homodimeric protein composed of 142 residue subunits, is a novel serine protease inhibitor present in Escherichia coli. Its thermostability and acid stability, as well as broad specificity toward proteases, make it an interesting protein for structural characterization. Its structure in the uncomplexed state, determined for two different crystalline environments, allows a structural comparison of the free inhibitor with that in complex with trypsin. Although there is no gross structural rearrangement of ecotin when binding trypsin, the loops involved in binding trypsin show relatively large shifts in atomic positions. The inherent flexibility of the loops and the highly nonglobular shape are the two features essential for its inhibitory function. An insight into the understanding of the structural basis of thermostability and acid stability of ecotin is also provided by the present structure.
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===PROTEASE INHIBITOR ECOTIN===
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Crystal structure analyses of uncomplexed ecotin in two crystal forms: implications for its function and stability.,Shin DH, Song HK, Seong IS, Lee CS, Chung CH, Suh SW Protein Sci. 1996 Nov;5(11):2236-47. PMID:8931142<ref>PMID:8931142</ref>
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{{ABSTRACT_PUBMED_8931142}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1ecy" style="background-color:#fffaf0;"></div>
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[[1ecy]] is a 1 chain structure of [[Ecotin]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ECY OCA].
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==See Also==
==See Also==
*[[Ecotin|Ecotin]]
*[[Ecotin|Ecotin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:008931142</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Shin, D H.]]
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[[Category: Large Structures]]
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[[Category: Suh, S W.]]
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[[Category: Shin DH]]
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[[Category: Beta-sheet structure]]
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[[Category: Suh SW]]
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[[Category: Periplasmic]]
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[[Category: Protease inhibitor]]
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[[Category: Serine protease inhibitor]]
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Current revision

PROTEASE INHIBITOR ECOTIN

PDB ID 1ecy

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