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1g55

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[[Image:1g55.png|left|200px]]
 
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{{STRUCTURE_1g55| PDB=1g55 | SCENE= }}
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==Structure of human DNMT2, an enigmatic DNA methyltransferase homologue==
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<StructureSection load='1g55' size='340' side='right'caption='[[1g55]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Structure of human DNMT2, an enigmatic DNA methyltransferase homologue===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1g55]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G55 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11139614}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g55 OCA], [https://pdbe.org/1g55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g55 RCSB], [https://www.ebi.ac.uk/pdbsum/1g55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g55 ProSAT]</span></td></tr>
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[[1g55]] is a 1 chain structure of [[DNA methyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G55 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRDMT_HUMAN TRDMT_HUMAN] Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).<ref>PMID:16424344</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/1g55_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g55 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA methyltransferase|DNA methyltransferase]]
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011139614</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bestor, T H.]]
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[[Category: Large Structures]]
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[[Category: Cheng, X.]]
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[[Category: Bestor TH]]
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[[Category: Dong, A.]]
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[[Category: Cheng X]]
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[[Category: Yoder, J A.]]
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[[Category: Dong A]]
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[[Category: Zhang, X.]]
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[[Category: Yoder JA]]
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[[Category: Zhou, L.]]
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[[Category: Zhang X]]
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[[Category: Human dna methyltransferase homologue]]
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[[Category: Zhou L]]
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[[Category: Transferase]]
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Current revision

Structure of human DNMT2, an enigmatic DNA methyltransferase homologue

PDB ID 1g55

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