This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1p6k

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:05, 14 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1p6k.png|left|200px]]
 
-
{{STRUCTURE_1p6k| PDB=1p6k | SCENE= }}
+
==Rat neuronal NOS D597N mutant heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound==
-
 
+
<StructureSection load='1p6k' size='340' side='right'caption='[[1p6k]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
-
===Rat neuronal NOS D597N mutant heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1p6k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P6K FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_14718923}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DP1:L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC+AMIDE'>DP1</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MTL:D-MANNITOL'>MTL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6k OCA], [https://pdbe.org/1p6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p6k RCSB], [https://www.ebi.ac.uk/pdbsum/1p6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p6k ProSAT]</span></td></tr>
-
[[1p6k]] is a 2 chain structure of [[Nitric Oxide Synthase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P6K OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p6/1p6k_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p6k ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
+
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:014718923</ref><references group="xtra"/>
+
[[Category: Large Structures]]
-
[[Category: Nitric-oxide synthase]]
+
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Flinspach, M L.]]
+
[[Category: Flinspach ML]]
-
[[Category: Gomez-Vidal, J A.]]
+
[[Category: Gomez-Vidal JA]]
-
[[Category: Hah, J M.]]
+
[[Category: Hah J-M]]
-
[[Category: Huang, H.]]
+
[[Category: Huang H]]
-
[[Category: Jamal, J.]]
+
[[Category: Jamal J]]
-
[[Category: Li, H.]]
+
[[Category: Li H]]
-
[[Category: Litzinger, E A.]]
+
[[Category: Litzinger EA]]
-
[[Category: Poulos, T L.]]
+
[[Category: Poulos TL]]
-
[[Category: Silverman, R B.]]
+
[[Category: Silverman RB]]
-
[[Category: Yang, W.]]
+
[[Category: Yang W]]
-
[[Category: Heme-enzyme]]
+
-
[[Category: Nitric oxide synthase]]
+
-
[[Category: Oxidoreductase]]
+

Current revision

Rat neuronal NOS D597N mutant heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound

PDB ID 1p6k

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1p6k"
Personal tools