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1leg

From Proteopedia

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[[Image:1leg.png|left|200px]]
 
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{{STRUCTURE_1leg| PDB=1leg | SCENE= }}
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==Crystal Structure of H-2Kb bound to the dEV8 peptide==
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<StructureSection load='1leg' size='340' side='right'caption='[[1leg]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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===Crystal Structure of H-2Kb bound to the dEV8 peptide===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1leg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LEG FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11994422}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1leg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1leg OCA], [https://pdbe.org/1leg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1leg RCSB], [https://www.ebi.ac.uk/pdbsum/1leg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1leg ProSAT]</span></td></tr>
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[[1leg]] is a 3 chain structure of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LEG OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NDUA4_MOUSE NDUA4_MOUSE] Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/le/1leg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1leg ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[Major histocompatibility complex|Major histocompatibility complex]]
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*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC I 3D structures|MHC I 3D structures]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:011994422</ref><ref group="xtra">PMID:015213391</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Apostolopoulos, V.]]
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[[Category: Apostolopoulos V]]
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[[Category: Garcia, K C.]]
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[[Category: Garcia KC]]
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[[Category: Huang, M.]]
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[[Category: Huang M]]
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[[Category: Luz, J G.]]
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[[Category: Luz JG]]
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[[Category: Rudolph, M G.]]
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[[Category: Rudolph MG]]
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[[Category: Teyton, L.]]
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[[Category: Teyton L]]
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[[Category: Wilson, I A.]]
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[[Category: Wilson IA]]
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[[Category: Immune system]]
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[[Category: Mhc class i molecule with bound peptide]]
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Current revision

Crystal Structure of H-2Kb bound to the dEV8 peptide

PDB ID 1leg

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