1bdg

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[[Image:1bdg.png|left|200px]]
 
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{{STRUCTURE_1bdg| PDB=1bdg | SCENE= }}
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==HEXOKINASE FROM SCHISTOSOMA MANSONI COMPLEXED WITH GLUCOSE==
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<StructureSection load='1bdg' size='340' side='right'caption='[[1bdg]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>The February 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''The Glycolytic Enzymes'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_2 10.2210/rcsb_pdb/mom_2004_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BDG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bdg OCA], [https://pdbe.org/1bdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bdg RCSB], [https://www.ebi.ac.uk/pdbsum/1bdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bdg ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/1bdg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bdg ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the structures of the glucose-6-phosphate (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a resolution of 2.8 and 2.6 A respectively. The structures define the glucose and G6P binding sites in these enzymes, suggest the mechanisms of intradomain G6P inhibition and activity loss in the Type I hexokinase N-terminal half, and reveal the structure of the membrane targeting motif that integrates the Type I hexokinase into the outer mitochondrial membrane.
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===HEXOKINASE FROM SCHISTOSOMA MANSONI COMPLEXED WITH GLUCOSE===
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The structure of mammalian hexokinase-1.,Mulichak AM, Wilson JE, Padmanabhan K, Garavito RM Nat Struct Biol. 1998 Jul;5(7):555-60. PMID:9665168<ref>PMID:9665168</ref>
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{{ABSTRACT_PUBMED_9665168}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1bdg" style="background-color:#fffaf0;"></div>
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[[1bdg]] is a 1 chain structure of [[Hexokinase]] with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. The February 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''The Glycolytic Enzymes'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2004_2 10.2210/rcsb_pdb/mom_2004_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BDG OCA].
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==See Also==
==See Also==
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*[[Hexokinase|Hexokinase]]
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*[[Hexokinase 3D structures|Hexokinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009665168</ref><references group="xtra"/>
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__TOC__
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[[Category: Hexokinase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Schistosoma mansoni]]
 
[[Category: The Glycolytic Enzymes]]
[[Category: The Glycolytic Enzymes]]
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[[Category: Garavito, R M.]]
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[[Category: Garavito RM]]
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[[Category: Mulichak, A M.]]
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[[Category: Mulichak AM]]
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[[Category: Hexokinase]]
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[[Category: Phosphotransferase]]
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Current revision

HEXOKINASE FROM SCHISTOSOMA MANSONI COMPLEXED WITH GLUCOSE

PDB ID 1bdg

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