3m9d

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[[Image:3m9d.png|left|200px]]
 
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{{STRUCTURE_3m9d| PDB=3m9d | SCENE= }}
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==Crystal structure of the prokaryotic ubiquintin-like protein Pup complexed with the hexameric proteasomal ATPase Mpa which includes the amino terminal coiled coil domain and the inter domain==
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<StructureSection load='3m9d' size='340' side='right'caption='[[3m9d]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
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===Crystal structure of the prokaryotic ubiquintin-like protein Pup complexed with the hexameric proteasomal ATPase Mpa which includes the amino terminal coiled coil domain and the inter domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3m9d]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M9D FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20953180}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m9d OCA], [https://pdbe.org/3m9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m9d RCSB], [https://www.ebi.ac.uk/pdbsum/3m9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m9d ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3m9d]] is a 18 chain structure of [[ATPase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M9D OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/ARC_MYCTU ARC_MYCTU] ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Is required but not sufficient to confer resistance against the lethal effects of reactive nitrogen intermediates (RNI), antimicrobial molecules produced by activated macrophages and other cell types.[HAMAP-Rule:MF_02112]<ref>PMID:14671303</ref> <ref>PMID:15659170</ref> <ref>PMID:17082771</ref> <ref>PMID:19836337</ref> <ref>PMID:20203624</ref>
==See Also==
==See Also==
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*[[ATPase|ATPase]]
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*[[ATPase 3D structures|ATPase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020953180</ref><references group="xtra"/>
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__TOC__
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[[Category: Mycobacterium tuberculosis]]
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</StructureSection>
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[[Category: Li, H.]]
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[[Category: Large Structures]]
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[[Category: Wang, T.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: 5 beta-strand barrel]]
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[[Category: Li H]]
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[[Category: Alpha helix coil coil]]
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[[Category: Wang T]]
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[[Category: Atp-binding]]
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[[Category: Chaperone]]
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[[Category: Isopeptide bond]]
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[[Category: Nucleotide-binding]]
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[[Category: Proteasome]]
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[[Category: S-nitrosylation]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Virulence]]
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Current revision

Crystal structure of the prokaryotic ubiquintin-like protein Pup complexed with the hexameric proteasomal ATPase Mpa which includes the amino terminal coiled coil domain and the inter domain

PDB ID 3m9d

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