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| - | [[Image:1h6w.gif|left|200px]]<br /><applet load="1h6w" size="350" color="white" frame="true" align="right" spinBox="true" | + | #REDIRECT [[5lye]] This PDB entry is obsolete and replaced by 5lye |
| - | caption="1h6w, resolution 1.90Å" />
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| - | '''CRYSTAL STRUCTURE OF A HEAT-AND PROTEASE-STABLE FRAGMENT OF THE BACTERIOPHAGE T4 SHORT FIBRE'''<br />
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| - | ==Overview==
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| - | Adsorption of T4 bacteriophage to the Escherichia coli host cell is mediated by six long and six short tail fibres. After at least three long tail fibres have bound, short tail fibres extend and bind irreversibly to the core region of the host cell lipopolysaccharide (LPS), serving as inextensible stays during penetration of the cell envelope by the tail tube. The short tail fibres consist of a parallel, in-register, trimer of gene product 12 (gp12). The 1.9 A crystal structure of a heat and protease-stable fragment of gp12 reveals three new folds: a central right-handed triple beta-helix, a globular C-terminal domain containing a beta-sandwich and an N-terminal beta-structure reminiscent of but different from the adenovirus triple beta-spiral. The centre of the C-terminal domain shows weak homology to gp11, a trimeric protein connecting the short fibre to the base-plate, suggesting that the trimerisation motifs of gp11 and gp12 are similar. Repeating sequence motifs suggest that the N-terminal beta-structure extends further towards the N terminus and is conserved in the long tail fibre proteins gp34 and gp37.
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| - | ==About this Structure==
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| - | 1H6W is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bacteriophage_t4 Bacteriophage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6W OCA].
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| - | ==Reference==
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| - | Crystal structure of a heat and protease-stable part of the bacteriophage T4 short tail fibre., van Raaij MJ, Schoehn G, Burda MR, Miller S, J Mol Biol. 2001 Dec 14;314(5):1137-46. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11743729 11743729]
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| - | [[Category: Bacteriophage t4]]
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| - | [[Category: Protein complex]]
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| - | [[Category: Burda, M R.]]
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| - | [[Category: Miller, S.]]
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| - | [[Category: Raaij, M J.Van.]]
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| - | [[Category: Schoehn, G.]]
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| - | [[Category: adhesin]]
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| - | [[Category: fibrous protein]]
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| - | [[Category: gene product 12]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:58:07 2008''
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