1zbb

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[[Image:1zbb.png|left|200px]]
 
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{{STRUCTURE_1zbb| PDB=1zbb | SCENE= }}
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==Structure of the 4_601_167 Tetranucleosome==
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<StructureSection load='1zbb' size='340' side='right'caption='[[1zbb]], [[Resolution|resolution]] 9.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zbb]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZBB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zbb OCA], [https://pdbe.org/1zbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zbb RCSB], [https://www.ebi.ac.uk/pdbsum/1zbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zbb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zb/1zbb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zbb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DNA in eukaryotic chromosomes is organized in arrays of nucleosomes compacted into chromatin fibres. This higher-order structure of nucleosomes is the substrate for DNA replication, recombination, transcription and repair. Although the structure of the nucleosome core is known at near-atomic resolution, even the most fundamental information about the organization of nucleosomes in the fibre is controversial. Here we report the crystal structure of an oligonucleosome (a compact tetranucleosome) at 9 A resolution, solved by molecular replacement using the nucleosome core structure. The structure shows that linker DNA zigzags back and forth between two stacks of nucleosome cores, which form a truncated two-start helix, and does not follow a path compatible with a one-start solenoidal helix. The length of linker DNA is most probably buffered by stretching of the DNA contained in the nucleosome cores. We have built continuous fibre models by successively stacking tetranucleosomes one on another. The resulting models are nearly fully compacted and most closely resemble the previously described crossed-linker model. They suggest that the interfaces between nucleosomes along a single helix start are polymorphic.
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===Structure of the 4_601_167 Tetranucleosome===
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X-ray structure of a tetranucleosome and its implications for the chromatin fibre.,Schalch T, Duda S, Sargent DF, Richmond TJ Nature. 2005 Jul 7;436(7047):138-41. PMID:16001076<ref>PMID:16001076</ref>
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{{ABSTRACT_PUBMED_16001076}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1zbb" style="background-color:#fffaf0;"></div>
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[[1zbb]] is a 18 chain structure of [[Histone]] with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZBB OCA].
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==See Also==
==See Also==
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*[[Histone|Histone]]
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*[[Histone 3D structures|Histone 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016001076</ref><ref group="xtra">PMID:018160966</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: Duda, S.]]
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[[Category: Duda S]]
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[[Category: Richmond, T J.]]
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[[Category: Richmond TJ]]
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[[Category: Sargent, D F.]]
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[[Category: Sargent DF]]
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[[Category: Schalch, T.]]
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[[Category: Schalch T]]
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[[Category: Chromatin]]
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[[Category: Chromatin fiber]]
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[[Category: Histone]]
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[[Category: Nucleoprotein]]
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[[Category: Nucleosome]]
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[[Category: Nucleosome core]]
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[[Category: Protein-dna complex]]
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[[Category: Protein-dna interaction]]
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[[Category: Structural protein-dna complex]]
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[[Category: Supercoiled dna]]
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[[Category: Tetranucleosome]]
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Current revision

Structure of the 4_601_167 Tetranucleosome

PDB ID 1zbb

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