1dut

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[[Image:1dut.png|left|200px]]
 
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{{STRUCTURE_1dut| PDB=1dut | SCENE= }}
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==FIV DUTP PYROPHOSPHATASE==
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<StructureSection load='1dut' size='340' side='right'caption='[[1dut]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===FIV DUTP PYROPHOSPHATASE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dut]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Feline_immunodeficiency_virus_(isolate_Petaluma) Feline immunodeficiency virus (isolate Petaluma)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DUT FirstGlance]. <br>
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{{ABSTRACT_PUBMED_8976551}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dut OCA], [https://pdbe.org/1dut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dut RCSB], [https://www.ebi.ac.uk/pdbsum/1dut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dut ProSAT]</span></td></tr>
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[[1dut]] is a 2 chain structure of [[Deoxyuridine 5'-triphosphate nucleotidohydrolase]] with sequence from [http://en.wikipedia.org/wiki/Feline_immunodeficiency_virus Feline immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUT OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POL_FIVPE POL_FIVPE] During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/1dut_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dut ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
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*[[DUTPase 3D structures|DUTPase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:008976551</ref><ref group="xtra">PMID:009878436</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Feline immunodeficiency virus]]
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[[Category: Elder JH]]
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[[Category: DUTP diphosphatase]]
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[[Category: Hasselkus-Light C]]
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[[Category: Elder, J H.]]
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[[Category: Laco GS]]
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[[Category: Hasselkus-Light, C.]]
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[[Category: Mcree DE]]
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[[Category: Laco, G S.]]
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[[Category: Prasad GS]]
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[[Category: Mcree, D E.]]
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[[Category: Stout CD]]
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[[Category: Prasad, G S.]]
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[[Category: Stura EA]]
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[[Category: Stout, C D.]]
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[[Category: Stura, E A.]]
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[[Category: Acid anhydride hydrolase]]
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[[Category: Aspartyl protease]]
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[[Category: Endonuclease]]
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[[Category: Hydrolase]]
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[[Category: Nucleotide metabolism]]
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[[Category: Polyprotein]]
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[[Category: Rna-directed dna polymerase]]
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Current revision

FIV DUTP PYROPHOSPHATASE

PDB ID 1dut

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