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1mlw

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[[Image:1mlw.png|left|200px]]
 
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{{STRUCTURE_1mlw| PDB=1mlw | SCENE= }}
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==Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III)==
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<StructureSection load='1mlw' size='340' side='right'caption='[[1mlw]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
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===Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mlw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The January 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phenylalanine Hydroxylase'' by Shuchismita Dutta and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_1 10.2210/rcsb_pdb/mom_2005_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MLW FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12379098}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mlw OCA], [https://pdbe.org/1mlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mlw RCSB], [https://www.ebi.ac.uk/pdbsum/1mlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mlw ProSAT]</span></td></tr>
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[[1mlw]] is a 1 chain structure of [[Tryptophan hydroxylase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The January 2005 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phenylalanine Hydroxylase'' by Shuchismita Dutta and David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2005_1 10.2210/rcsb_pdb/mom_2005_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MLW OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TPH1_HUMAN TPH1_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ml/1mlw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mlw ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Tryptophan hydroxylase|Tryptophan hydroxylase]]
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*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]
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*[[Tryptophan hydroxylase 1 with bound tryptophan|Tryptophan hydroxylase 1 with bound tryptophan]]
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*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:012379098</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Phenylalanine Hydroxylase]]
[[Category: Phenylalanine Hydroxylase]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Tryptophan 5-monooxygenase]]
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[[Category: Erlandsen H]]
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[[Category: Erlandsen, H.]]
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[[Category: Haavik J]]
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[[Category: Haavik, J.]]
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[[Category: Knappskog PM]]
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[[Category: Knappskog, P M.]]
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[[Category: Stevens RC]]
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[[Category: Stevens, R C.]]
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[[Category: Wang L]]
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[[Category: Wang, L.]]
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[[Category: Aromatic amino acid hydroxylase catalytic domain fold]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III)

PDB ID 1mlw

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