3dab

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3dab" [edit=sysop:move=sysop])
Current revision (15:06, 1 November 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3dab.png|left|200px]]
 
-
{{STRUCTURE_3dab| PDB=3dab | SCENE= }}
+
==Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain==
 +
<StructureSection load='3dab' size='340' side='right'caption='[[3dab]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3dab]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAB FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dab OCA], [https://pdbe.org/3dab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dab RCSB], [https://www.ebi.ac.uk/pdbsum/3dab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dab ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dab_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dab ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human p53. The structure shows why antagonists of the Mdm2 binding to p53 are ineffective in the Mdmx-p53 interaction.
-
===Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain===
+
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.,Popowicz GM, Czarna A, Holak TA Cell Cycle. 2008 Aug;7(15):2441-3. Epub 2008 May 27. PMID:18677113<ref>PMID:18677113</ref>
-
{{ABSTRACT_PUBMED_18677113}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 3dab" style="background-color:#fffaf0;"></div>
-
[[3dab]] is a 8 chain structure of [[MDM4]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAB OCA].
+
==See Also==
==See Also==
*[[MDM4|MDM4]]
*[[MDM4|MDM4]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:018677113</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Czarna, A.]]
+
[[Category: Large Structures]]
-
[[Category: Holak, T A.]]
+
[[Category: Czarna A]]
-
[[Category: Popowicz, G M.]]
+
[[Category: Holak TA]]
-
[[Category: Apoptosis]]
+
[[Category: Popowicz GM]]
-
[[Category: Cell cycle]]
+
-
[[Category: Disease mutation]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Hdm2]]
+
-
[[Category: Hdm4]]
+
-
[[Category: Hdmx]]
+
-
[[Category: Mdm-4]]
+
-
[[Category: Mdm-x]]
+
-
[[Category: Mdm2]]
+
-
[[Category: Mdm4]]
+
-
[[Category: Mdmx]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Oncogene]]
+
-
[[Category: P53]]
+
-
[[Category: Transcription]]
+
-
[[Category: Tumor]]
+

Current revision

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

PDB ID 3dab

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3dab"
Personal tools