2vd3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2vd3" [edit=sysop:move=sysop])
Current revision (09:57, 9 May 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2vd3.png|left|200px]]
 
-
{{STRUCTURE_2vd3| PDB=2vd3 | SCENE= }}
+
==The structure of histidine inhibited HisG from Methanobacterium thermoautotrophicum==
-
 
+
<StructureSection load='2vd3' size='340' side='right'caption='[[2vd3]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-
===THE STRUCTURE OF HISTIDINE INHIBITED HISG FROM METHANOBACTERIUM THERMOAUTOTROPHICUM===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2vd3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._Delta_H Methanothermobacter thermautotrophicus str. Delta H]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VD3 FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
-
==About this Structure==
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
-
[[2vd3]] is a 2 chain structure of [[ATP Phosphoribosyl Transferase]] with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD3 OCA].
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd3 OCA], [https://pdbe.org/2vd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vd3 RCSB], [https://www.ebi.ac.uk/pdbsum/2vd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vd3 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HIS1_METTH HIS1_METTH] Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vd3_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vd3 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[ATP Phosphoribosyl Transferase|ATP Phosphoribosyl Transferase]]
+
*[[ATP phosphoribosyl transferase 3D structures|ATP phosphoribosyl transferase 3D structures]]
-
[[Category: ATP phosphoribosyltransferase]]
+
__TOC__
-
[[Category: Methanothermobacter thermautotrophicus]]
+
</StructureSection>
-
[[Category: Lapthorn, A J.]]
+
[[Category: Large Structures]]
-
[[Category: Lohkamp, B.]]
+
[[Category: Methanothermobacter thermautotrophicus str. Delta H]]
-
[[Category: Schweikert, T.]]
+
[[Category: Lapthorn AJ]]
-
[[Category: Amino-acid biosynthesis]]
+
[[Category: Lohkamp B]]
-
[[Category: Atp phosphoribosyl transferase]]
+
[[Category: Schweikert T]]
-
[[Category: Glycosyltransferase]]
+
-
[[Category: Hisg]]
+
-
[[Category: Histidine]]
+
-
[[Category: Histidine biosynthesis]]
+
-
[[Category: Magnesium]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Transferase]]
+

Current revision

The structure of histidine inhibited HisG from Methanobacterium thermoautotrophicum

PDB ID 2vd3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vd3"
Personal tools