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3to7

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[[Image:3to7.png|left|200px]]
 
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{{STRUCTURE_3to7| PDB=3to7 | SCENE= }}
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==Crystal structure of yeast Esa1 HAT domain bound to coenzyme A with active site lysine acetylated==
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<StructureSection load='3to7' size='340' side='right'caption='[[3to7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Crystal structure of yeast Esa1 HAT domain bound to coenzyme A with active site lysine acetylated===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3to7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TO7 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22020126}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CAD:CACODYLIC+ACID'>CAD</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3to7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3to7 OCA], [https://pdbe.org/3to7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3to7 RCSB], [https://www.ebi.ac.uk/pdbsum/3to7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3to7 ProSAT]</span></td></tr>
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[[3to7]] is a 1 chain structure of [[Histone acetyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TO7 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ESA1_YEAST ESA1_YEAST] Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A.Z to form H2A.ZK14ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me.<ref>PMID:9858608</ref> <ref>PMID:10082517</ref> <ref>PMID:10835360</ref> <ref>PMID:10911987</ref> <ref>PMID:12353039</ref> <ref>PMID:15175650</ref> <ref>PMID:15494307</ref> <ref>PMID:15045029</ref> <ref>PMID:15923609</ref>
==See Also==
==See Also==
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*[[Histone acetyltransferase|Histone acetyltransferase]]
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022020126</ref><references group="xtra"/>
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__TOC__
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[[Category: Histone acetyltransferase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Ding, E C.]]
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[[Category: Ding EC]]
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[[Category: Marmorstein, R.]]
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[[Category: Marmorstein R]]
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[[Category: Yuan, H.]]
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[[Category: Yuan H]]
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[[Category: Histone acetyltransferase]]
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[[Category: Myst family]]
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[[Category: Transferase]]
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Current revision

Crystal structure of yeast Esa1 HAT domain bound to coenzyme A with active site lysine acetylated

PDB ID 3to7

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