2pxy

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[[Image:2pxy.png|left|200px]]
 
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{{STRUCTURE_2pxy| PDB=2pxy | SCENE= }}
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==Crystal structures of immune receptor complexes==
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<StructureSection load='2pxy' size='340' side='right'caption='[[2pxy]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2pxy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PXY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pxy OCA], [https://pdbe.org/2pxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pxy RCSB], [https://www.ebi.ac.uk/pdbsum/2pxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pxy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HA2U_MOUSE HA2U_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/px/2pxy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pxy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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All complexes of T cell receptors (TCRs) bound to peptide-major histocompatibility complex (pMHC) molecules assume a stereotyped binding 'polarity', despite wide variations in TCR-pMHC docking angles. However, existing TCR-pMHC crystal structures have failed to show broadly conserved pairwise interaction motifs. Here we determined the crystal structures of two TCRs encoded by the variable beta-chain 8.2 (V(beta)8.2), each bound to the MHC class II molecule I-A(u), and did energetic mapping of V(alpha) and V(beta) contacts with I-A(u). Together with two previously solved structures of V(beta)8.2-containing TCR-MHC complexes, we found four TCR-I-A complexes with structurally superimposable interactions between the V(beta) loops and the I-A alpha-helix. This examination of a narrow 'slice' of the TCR-MHC repertoire demonstrates what is probably one of many germline-derived TCR-MHC interaction 'codons'.
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===Crystal structures of immune receptor complexes===
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Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.,Feng D, Bond CJ, Ely LK, Maynard J, Garcia KC Nat Immunol. 2007 Sep;8(9):975-83. Epub 2007 Aug 12. PMID:17694060<ref>PMID:17694060</ref>
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{{ABSTRACT_PUBMED_17694060}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2pxy" style="background-color:#fffaf0;"></div>
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[[2pxy]] is a 5 chain structure of [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXY OCA].
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==See Also==
==See Also==
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*[[Major histocompatibility complex|Major histocompatibility complex]]
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*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC II 3D structures|MHC II 3D structures]]
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==Reference==
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*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
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<ref group="xtra">PMID:017694060</ref><references group="xtra"/>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Bond, C J.]]
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[[Category: Bond CJ]]
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[[Category: Ely, L K.]]
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[[Category: Ely LK]]
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[[Category: Feng, D.]]
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[[Category: Feng D]]
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[[Category: Garcia, K C.]]
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[[Category: Garcia KC]]
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[[Category: Complex]]
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[[Category: Immune system]]
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Current revision

Crystal structures of immune receptor complexes

PDB ID 2pxy

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