2w65

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2w65" [edit=sysop:move=sysop])
Current revision (08:45, 15 November 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2w65.png|left|200px]]
 
-
{{STRUCTURE_2w65| PDB=2w65 | SCENE= }}
+
==Anti citrullinated Collagen type 2 antibody acc4 in complex with a citrullinated peptide==
 +
<StructureSection load='2w65' size='340' side='right'caption='[[2w65]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2w65]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W65 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w65 OCA], [https://pdbe.org/2w65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w65 RCSB], [https://www.ebi.ac.uk/pdbsum/2w65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w65 ProSAT]</span></td></tr>
 +
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/2w65_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w65 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear. To obtain insight into this question, a panel of mouse monoclonal antibodies was generated against a major triple helical collagen type II (CII) epitope (position 359-369; ARGLTGRPGDA) with or without arginines modified by citrullination. These antibodies bind cartilage and synovial tissue, and mediate arthritis in mice. Detection of citrullinated CII from RA patients' synovial fluid demonstrates that cartilage-derived CII is indeed citrullinated in vivo. The structure determination of a Fab fragment of one of these antibodies in complex with a citrullinated peptide showed a surprising beta-turn conformation of the peptide and provided information on citrulline recognition. Based on these findings, we propose that autoimmunity to CII, leading to the production of antibodies specific for both native and citrullinated CII, is an important pathogenic factor in the development of RA.
-
===ANTI CITRULLINATED COLLAGEN TYPE 2 ANTIBODY ACC4 IN COMPLEX WITH A CITRULLINATED PEPTIDE===
+
Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.,Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engstrom A, Serre G, Burkhardt H, Thunnissen MM, Holmdahl R J Exp Med. 2009 Feb 16;206(2):449-62. Epub 2009 Feb 9. PMID:19204106<ref>PMID:19204106</ref>
-
{{ABSTRACT_PUBMED_19204106}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 2w65" style="background-color:#fffaf0;"></div>
-
[[2w65]] is a 6 chain structure of [[Monoclonal Antibody]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W65 OCA].
+
==See Also==
==See Also==
-
*[[Monoclonal Antibody|Monoclonal Antibody]]
+
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:019204106</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Bajtner, E.]]
+
[[Category: Bajtner E]]
-
[[Category: Bockermann, R.]]
+
[[Category: Bockermann R]]
-
[[Category: Burkhardt, H.]]
+
[[Category: Burkhardt H]]
-
[[Category: Engstrom, A.]]
+
[[Category: Engstrom A]]
-
[[Category: Holmdahl, R.]]
+
[[Category: Holmdahl R]]
-
[[Category: Nandakumar, K S.]]
+
[[Category: Nandakumar KS]]
-
[[Category: Sehnert, B.]]
+
[[Category: Sehnert B]]
-
[[Category: Serre, G.]]
+
[[Category: Serre G]]
-
[[Category: Thunnissen, M M.G M.]]
+
[[Category: Thunnissen MMGM]]
-
[[Category: Uysal, H.]]
+
[[Category: Uysal H]]
-
[[Category: Antibody anti-citrullin]]
+
-
[[Category: Arthritis]]
+
-
[[Category: Collagen type ii]]
+
-
[[Category: Immune system]]
+

Current revision

Anti citrullinated Collagen type 2 antibody acc4 in complex with a citrullinated peptide

PDB ID 2w65

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2w65"
Personal tools