2pno

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[[Image:2pno.png|left|200px]]
 
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{{STRUCTURE_2pno| PDB=2pno | SCENE= }}
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==Crystal structure of human leukotriene C4 synthase==
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<StructureSection load='2pno' size='340' side='right'caption='[[2pno]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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===Crystal structure of human leukotriene C4 synthase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2pno]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PNO FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17632548}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pno OCA], [https://pdbe.org/2pno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pno RCSB], [https://www.ebi.ac.uk/pdbsum/2pno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pno ProSAT]</span></td></tr>
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[[2pno]] is a 12 chain structure of [[Leukotriene C4 synthase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNO OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[https://omim.org/entry/246530 246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
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== Function ==
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/2pno_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pno ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Leukotriene C4 synthase|Leukotriene C4 synthase]]
*[[Leukotriene C4 synthase|Leukotriene C4 synthase]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017632548</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ago, H.]]
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[[Category: Large Structures]]
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[[Category: Austen, K F.]]
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[[Category: Ago H]]
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[[Category: Irikura, D.]]
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[[Category: Austen KF]]
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[[Category: Kanaoka, Y.]]
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[[Category: Irikura D]]
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[[Category: Lam, B K.]]
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[[Category: Kanaoka Y]]
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[[Category: Miyano, M.]]
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[[Category: Lam BK]]
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[[Category: Shimamura, T.]]
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[[Category: Miyano M]]
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[[Category: Helix bundle]]
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[[Category: Shimamura T]]
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[[Category: Homo trimer]]
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[[Category: Lyase]]
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[[Category: Mapeg]]
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[[Category: Membrane protein]]
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[[Category: Mgst]]
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Current revision

Crystal structure of human leukotriene C4 synthase

PDB ID 2pno

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