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2yl2
From Proteopedia
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| - | [[Image:2yl2.png|left|200px]] | ||
| - | + | ==Crystal structure of human acetyl-CoA carboxylase 1, biotin carboxylase (BC) domain== | |
| - | + | <StructureSection load='2yl2' size='340' side='right'caption='[[2yl2]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2yl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YL2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yl2 OCA], [https://pdbe.org/2yl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yl2 RCSB], [https://www.ebi.ac.uk/pdbsum/2yl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yl2 ProSAT]</span></td></tr> |
| - | [[2yl2]] is a 2 chain structure | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[https://omim.org/entry/613933 613933]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Beltrami A]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Froese | + | [[Category: Froese DS]] |
| - | [[Category: Krojer | + | [[Category: Krojer T]] |
| - | [[Category: Krysztofinska | + | [[Category: Krysztofinska E]] |
| - | [[Category: Muniz | + | [[Category: Muniz JRC]] |
| - | [[Category: Oppermann | + | [[Category: Oppermann U]] |
| - | [[Category: Vollmar | + | [[Category: Vollmar M]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Yue | + | [[Category: Yue WW]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
Current revision
Crystal structure of human acetyl-CoA carboxylase 1, biotin carboxylase (BC) domain
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Beltrami A | Bountra C | Edwards AM | Froese DS | Krojer T | Krysztofinska E | Muniz JRC | Oppermann U | Vollmar M | Weigelt J | Yue WW | Von Delft F
