3u3k

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[[Image:3u3k.png|left|200px]]
 
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{{STRUCTURE_3u3k| PDB=3u3k | SCENE= }}
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==Crystal structure of hSULT1A1 bound to PAP and 2-Naphtol==
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<StructureSection load='3u3k' size='340' side='right'caption='[[3u3k]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
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===Crystal structure of hSULT1A1 bound to PAP and 2-Naphtol===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3u3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U3K FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22069470}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.36&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03V:NAPHTHALEN-2-OL'>03V</scene>, <scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3k OCA], [https://pdbe.org/3u3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u3k RCSB], [https://www.ebi.ac.uk/pdbsum/3u3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u3k ProSAT]</span></td></tr>
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[[3u3k]] is a 2 chain structure of [[Sulfotransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3K OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ST1A1_HUMAN ST1A1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.<ref>PMID:12471039</ref> <ref>PMID:16221673</ref>
==See Also==
==See Also==
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*[[Sulfotransferase|Sulfotransferase]]
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*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022069470</ref><references group="xtra"/>
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__TOC__
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[[Category: Aryl sulfotransferase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aharoni, A.]]
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[[Category: Large Structures]]
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[[Category: Berger, I.]]
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[[Category: Aharoni A]]
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[[Category: Guttman, C.]]
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[[Category: Berger I]]
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[[Category: Zarivach, R.]]
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[[Category: Guttman C]]
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[[Category: 2-naphtol]]
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[[Category: Zarivach R]]
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[[Category: Arylsulfotransferase]]
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[[Category: Binding site]]
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[[Category: Transferase]]
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Current revision

Crystal structure of hSULT1A1 bound to PAP and 2-Naphtol

PDB ID 3u3k

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