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1kbs

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[[Image:1kbs.png|left|200px]]
 
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{{STRUCTURE_1kbs| PDB=1kbs | SCENE= }}
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==SOLUTION STRUCTURE OF CARDIOTOXIN IV, NMR, 1 STRUCTURE==
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<StructureSection load='1kbs' size='340' side='right'caption='[[1kbs]]' scene=''>
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===SOLUTION STRUCTURE OF CARDIOTOXIN IV, NMR, 1 STRUCTURE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1kbs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KBS FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9398182}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kbs OCA], [https://pdbe.org/1kbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kbs RCSB], [https://www.ebi.ac.uk/pdbsum/1kbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kbs ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1kbs]] is a 1 chain structure of [[Cardiotoxin]] with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KBS OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/3SA4_NAJAT 3SA4_NAJAT] Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also shows lytic activities, but 2-fold more important than that of CTX-A2. It binds to the integrin alpha-V/beta-3 with a moderate affinity. Inhibits protein kinase C. It may interact with sulfatides in the cell membrane, which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induces mitochondrial swelling and fragmentation.<ref>PMID:16407244</ref> <ref>PMID:8448165</ref> <ref>PMID:9398182</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/1kbs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kbs ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cardiotoxin|Cardiotoxin]]
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*[[Cardiotoxin 3D structures|Cardiotoxin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009398182</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Naja atra]]
[[Category: Naja atra]]
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[[Category: Jayaraman, G.]]
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[[Category: Jayaraman G]]
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[[Category: Jeng, J Y.]]
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[[Category: Jeng JY]]
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[[Category: Kumar, T K.S.]]
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[[Category: Kumar TKS]]
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[[Category: Yu, C.]]
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[[Category: Yu C]]
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[[Category: Cardiotoxin]]
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[[Category: Cytotoxin]]
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[[Category: Multigene family]]
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[[Category: Venom]]
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Current revision

SOLUTION STRUCTURE OF CARDIOTOXIN IV, NMR, 1 STRUCTURE

PDB ID 1kbs

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