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1mf4

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[[Image:1mf4.png|left|200px]]
 
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{{STRUCTURE_1mf4| PDB=1mf4 | SCENE= }}
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==Structure-based design of potent and selective inhibitors of phospholipase A2: Crystal structure of the complex formed between phosholipase A2 from Naja Naja sagittifera and a designed peptide inhibitor at 1.9 A resolution==
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<StructureSection load='1mf4' size='340' side='right'caption='[[1mf4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Structure-based design of potent and selective inhibitors of phospholipase A2: Crystal structure of the complex formed between phosholipase A2 from Naja Naja sagittifera and a designed peptide inhibitor at 1.9 A resolution===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mf4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MF4 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14529280}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mf4 OCA], [https://pdbe.org/1mf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mf4 RCSB], [https://www.ebi.ac.uk/pdbsum/1mf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mf4 ProSAT]</span></td></tr>
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[[1mf4]] is a 2 chain structure of [[Phospholipase A2]] with sequence from [http://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF4 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2A3_NAJSG PA2A3_NAJSG] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mf/1mf4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mf4 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phospholipase A2|Phospholipase A2]]
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:014529280</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Naja sagittifera]]
[[Category: Naja sagittifera]]
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[[Category: Dey, S.]]
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[[Category: Dey S]]
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[[Category: Jabeen, T.]]
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[[Category: Jabeen T]]
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[[Category: Kaur, P.]]
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[[Category: Kaur P]]
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[[Category: Makker, J.]]
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[[Category: Makker J]]
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[[Category: Paramsivam, M.]]
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[[Category: Paramsivam M]]
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[[Category: Sharma, S.]]
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[[Category: Sharma S]]
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[[Category: Singh, R K.]]
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[[Category: Singh RK]]
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[[Category: Singh, T P.]]
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[[Category: Singh TP]]
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[[Category: Srinivasan, A.]]
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[[Category: Srinivasan A]]
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[[Category: Vikram, P.]]
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[[Category: Vikram P]]
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[[Category: Designed inhibitor]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Naja naja sagittifera]]
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[[Category: Phospholipase a2]]
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Current revision

Structure-based design of potent and selective inhibitors of phospholipase A2: Crystal structure of the complex formed between phosholipase A2 from Naja Naja sagittifera and a designed peptide inhibitor at 1.9 A resolution

PDB ID 1mf4

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