4g9z
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4g9z is ON HOLD Authors: Xue Jiang, Qingfeng Huang, Wenjian Wang, Haohao Dong, Hinh Ly, Yuying Liang, Changjiang Dong, Scottish Structural Proteomic...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression== | |
| + | <StructureSection load='4g9z' size='340' side='right'caption='[[4g9z]], [[Resolution|resolution]] 2.03Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4g9z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G9Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g9z OCA], [https://pdbe.org/4g9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g9z RCSB], [https://www.ebi.ac.uk/pdbsum/4g9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g9z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lassa virus Josiah]] | ||
| + | [[Category: Dong C]] | ||
| + | [[Category: Dong H]] | ||
| + | [[Category: Huang Q]] | ||
| + | [[Category: Jiang X]] | ||
| + | [[Category: Liang Y]] | ||
| + | [[Category: Ly H]] | ||
| + | [[Category: Wang W]] | ||
Current revision
Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression
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Categories: Large Structures | Lassa virus Josiah | Dong C | Dong H | Huang Q | Jiang X | Liang Y | Ly H | Wang W
