4gae
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of plasmodium dxr in complex with a pyridine-containing inhibitor== | |
| + | <StructureSection load='4gae' size='340' side='right'caption='[[4gae]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gae]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_HB3 Plasmodium falciparum HB3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FOB:[(1R)-3-[ACETYL(HYDROXY)AMINO]-1-(PYRIDIN-4-YL)PROPYL]PHOSPHONIC+ACID'>FOB</scene>, <scene name='pdbligand=FOQ:[(1S)-3-[ACETYL(HYDROXY)AMINO]-1-(PYRIDIN-4-YL)PROPYL]PHOSPHONIC+ACID'>FOQ</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gae OCA], [https://pdbe.org/4gae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gae RCSB], [https://www.ebi.ac.uk/pdbsum/4gae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gae ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DXR_PLAFX DXR_PLAFX] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).<ref>PMID:10477522</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[DXP reductoisomerase 3D Structures|DXP reductoisomerase 3D Structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Plasmodium falciparum HB3]] | ||
| + | [[Category: Cai G]] | ||
| + | [[Category: Deng L]] | ||
| + | [[Category: Diao J]] | ||
| + | [[Category: Song Y]] | ||
| + | [[Category: Xue J]] | ||
Current revision
Crystal structure of plasmodium dxr in complex with a pyridine-containing inhibitor
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Categories: Large Structures | Plasmodium falciparum HB3 | Cai G | Deng L | Diao J | Song Y | Xue J
