3ura

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[[Image:3ura.jpg|left|200px]]
 
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{{STRUCTURE_3ura| PDB=3ura | SCENE= }}
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==Crystal Structure of PTE mutant H254G/H257W/L303T/K185R/I274N/A80V/S61T==
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<StructureSection load='3ura' size='340' side='right'caption='[[3ura]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ura]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3URA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3URA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ura FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ura OCA], [https://pdbe.org/3ura PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ura RCSB], [https://www.ebi.ac.uk/pdbsum/3ura PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ura ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate.
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===Crystal Structure of PTE mutant H254G/H257W/L303T/K185R/I274N/A80V/S61T===
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==See Also==
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*[[Phosphotriesterase 3D structures|Phosphotriesterase 3D structures]]
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{{ABSTRACT_PUBMED_22809162}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3ura]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3URA OCA].
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==Reference==
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<ref group="xtra">PMID:022809162</ref><references group="xtra"/>
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[[Category: Aryldialkylphosphatase]]
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[[Category: Brevundimonas diminuta]]
[[Category: Brevundimonas diminuta]]
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[[Category: Barondeau, D P.]]
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[[Category: Large Structures]]
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[[Category: Fox, N G.]]
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[[Category: Barondeau DP]]
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[[Category: Li, Y.]]
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[[Category: Fox NG]]
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[[Category: Raushel, F M.]]
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[[Category: Li Y]]
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[[Category: Tsai, P.]]
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[[Category: Raushel FM]]
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[[Category: Hydrolase]]
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[[Category: Tsai P]]
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[[Category: Metalloenzyme]]
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[[Category: Nerve agent]]
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[[Category: Phosphotriesterase]]
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[[Category: Tim barrel]]
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Current revision

Crystal Structure of PTE mutant H254G/H257W/L303T/K185R/I274N/A80V/S61T

PDB ID 3ura

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