4duh

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[[Image:4duh.jpg|left|200px]]
 
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{{STRUCTURE_4duh| PDB=4duh | SCENE= }}
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==Crystal structure of 24 kDa domain of E. coli DNA gyrase B in complex with small molecule inhibitor==
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<StructureSection load='4duh' size='340' side='right'caption='[[4duh]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4duh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DUH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RLI:4-{[4-METHYL-2-(PROPANOYLAMINO)-4,5-BI-1,3-THIAZOL-2-YL]AMINO}BENZOIC+ACID'>RLI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4duh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4duh OCA], [https://pdbe.org/4duh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4duh RCSB], [https://www.ebi.ac.uk/pdbsum/4duh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4duh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GYRB_ECOLI GYRB_ECOLI] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.<ref>PMID:12051843</ref> <ref>PMID:18642932</ref> <ref>PMID:20675723</ref>
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===Crystal structure of 24 kDa domain of E. coli DNA gyrase B in complex with small molecule inhibitor===
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==See Also==
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*[[Gyrase 3D Structures|Gyrase 3D Structures]]
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{{ABSTRACT_PUBMED_22731783}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4duh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DUH OCA].
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:022731783</ref><references group="xtra"/>
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[[Category: Brvar M]]
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[[Category: Escherichia coli]]
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[[Category: Perdih A]]
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[[Category: Brvar, M.]]
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[[Category: Renko M]]
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[[Category: Perdih, A.]]
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[[Category: Solmajer T]]
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[[Category: Renko, M.]]
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[[Category: Turk D]]
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[[Category: Solmajer, T.]]
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[[Category: Turk, D.]]
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[[Category: Antibacterial]]
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[[Category: Dna gyrase b]]
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[[Category: Gyrase]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Structure-based drug design]]
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Current revision

Crystal structure of 24 kDa domain of E. coli DNA gyrase B in complex with small molecule inhibitor

PDB ID 4duh

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