4a7h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:33, 9 April 2025) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4a7h.jpg|left|200px]]
 
-
{{STRUCTURE_4a7h| PDB=4a7h | SCENE= }}
+
==Structure of the Actin-Tropomyosin-Myosin Complex (rigor ATM 2)==
 +
<SX load='4a7h' size='340' side='right' viewer='molstar' caption='[[4a7h]], [[Resolution|resolution]] 7.80&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4a7h]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A7H FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.8&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7h OCA], [https://pdbe.org/4a7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a7h RCSB], [https://www.ebi.ac.uk/pdbsum/4a7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a7h ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Regulation of myosin and filamentous actin interaction by tropomyosin is a central feature of contractile events in muscle and nonmuscle cells. However, little is known about molecular interactions within the complex and the trajectory of tropomyosin movement between its "open" and "closed" positions on the actin filament. Here, we report the 8 A resolution structure of the rigor (nucleotide-free) actin-tropomyosin-myosin complex determined by cryo-electron microscopy. The pseudoatomic model of the complex, obtained from fitting crystal structures into the map, defines the large interface involving two adjacent actin monomers and one tropomyosin pseudorepeat per myosin contact. Severe forms of hereditary myopathies are linked to mutations that critically perturb this interface. Myosin binding results in a 23 A shift of tropomyosin along actin. Complex domain motions occur in myosin, but not in actin. Based on our results, we propose a structural model for the tropomyosin-dependent modulation of myosin binding to actin.
-
===Structure of the Actin-Tropomyosin-Myosin Complex (rigor ATM 2)===
+
Structure of the rigor actin-tropomyosin-Myosin complex.,Behrmann E, Muller M, Penczek PA, Mannherz HG, Manstein DJ, Raunser S Cell. 2012 Jul 20;150(2):327-38. PMID:22817895<ref>PMID:22817895</ref>
-
{{ABSTRACT_PUBMED_22817895}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 4a7h" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[4a7h]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7H OCA].
+
*[[Actin 3D structures|Actin 3D structures]]
-
 
+
*[[Myosin 3D Structures|Myosin 3D Structures]]
-
==Reference==
+
*[[Tropomyosin 3D structures|Tropomyosin 3D structures]]
-
<ref group="xtra">PMID:022817895</ref><references group="xtra"/>
+
== References ==
 +
<references/>
 +
__TOC__
 +
</SX>
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
-
[[Category: Myosin ATPase]]
+
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
-
[[Category: Behrmann, E.]]
+
[[Category: Behrmann E]]
-
[[Category: Mannherz, H G.]]
+
[[Category: Mannherz HG]]
-
[[Category: Manstein, D J.]]
+
[[Category: Manstein DJ]]
-
[[Category: Mueller, M.]]
+
[[Category: Mueller M]]
-
[[Category: Penczek, P A.]]
+
[[Category: Penczek PA]]
-
[[Category: Raunser, S.]]
+
[[Category: Raunser S]]
-
[[Category: Actin binding]]
+
-
[[Category: Atp catabolic process]]
+
-
[[Category: Contractile filament]]
+
-
[[Category: Cytoskeleton]]
+
-
[[Category: Motor activity]]
+
-
[[Category: Myosin binding]]
+
-
[[Category: Rigor state]]
+
-
[[Category: Structural protein]]
+
-
[[Category: Structural protein-hydrolase complex]]
+

Current revision

Structure of the Actin-Tropomyosin-Myosin Complex (rigor ATM 2)

4a7h, resolution 7.80Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4a7h"
Personal tools