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1hzx

From Proteopedia

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[[Image:1hzx.gif|left|200px]]<br /><applet load="1hzx" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hzx, resolution 2.8&Aring;" />
 
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'''CRYSTAL STRUCTURE OF BOVINE RHODOPSIN'''<br />
 
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==About this Structure==
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==CRYSTAL STRUCTURE OF BOVINE RHODOPSIN==
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1HZX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=BNG:'>BNG</scene>, <scene name='pdbligand=HG:'>HG</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=ACE:'>ACE</scene>, <scene name='pdbligand=PLM:'>PLM</scene>, <scene name='pdbligand=RET:'>RET</scene> and <scene name='pdbligand=HTO:'>HTO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZX OCA].
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<StructureSection load='1hzx' size='340' side='right'caption='[[1hzx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hzx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HZX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=HTO:HEPTANE-1,2,3-TRIOL'>HTO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzx OCA], [https://pdbe.org/1hzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hzx RCSB], [https://www.ebi.ac.uk/pdbsum/1hzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/1hzx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hzx ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs)., Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE, Biochemistry. 2001 Jul 3;40(26):7761-72. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11425302 11425302]
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*[[Rhodopsin 3D structures|Rhodopsin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Behnke, C A.]]
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[[Category: Behnke CA]]
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[[Category: Okada, T.]]
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[[Category: Okada T]]
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[[Category: Palczewski, K.]]
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[[Category: Palczewski K]]
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[[Category: Stenkamp, R E.]]
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[[Category: Stenkamp RE]]
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[[Category: Teller, D C.]]
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[[Category: Teller DC]]
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[[Category: ACE]]
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[[Category: BNG]]
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[[Category: HG]]
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[[Category: HTO]]
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[[Category: PLM]]
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[[Category: RET]]
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[[Category: ZN]]
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[[Category: g-protein-coupled receptors]]
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[[Category: membrane protein photoreceptor cells]]
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[[Category: phototransduction]]
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[[Category: signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:06:33 2008''
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Current revision

CRYSTAL STRUCTURE OF BOVINE RHODOPSIN

PDB ID 1hzx

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