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3se4

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[[Image:3se4.png|left|200px]]
 
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{{STRUCTURE_3se4| PDB=3se4 | SCENE= }}
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==human IFNw-IFNAR ternary complex==
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<StructureSection load='3se4' size='340' side='right'caption='[[3se4]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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===human IFNw-IFNAR ternary complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3se4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SE4 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21854986}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5001&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3se4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3se4 OCA], [https://pdbe.org/3se4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3se4 RCSB], [https://www.ebi.ac.uk/pdbsum/3se4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3se4 ProSAT]</span></td></tr>
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[[3se4]] is a 3 chain structure of [[Multiple sclerosis]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SE4 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INAR1_HUMAN INAR1_HUMAN] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
==See Also==
==See Also==
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*[[Interactive 3D Complements in Proteopedia|Interactive 3D Complements in Proteopedia]]
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*[[Interferon 3D structures|Interferon 3D structures]]
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*[[Interferon|Interferon]]
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*[[Interferon receptor 3D structures|Interferon receptor 3D structures]]
*[[Multiple sclerosis|Multiple sclerosis]]
*[[Multiple sclerosis|Multiple sclerosis]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021854986</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Garcia, K C.]]
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[[Category: Large Structures]]
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[[Category: Thomas, C.]]
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[[Category: Garcia KC]]
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[[Category: Extracellular space]]
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[[Category: Thomas C]]
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[[Category: Immune system receptor]]
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[[Category: Type i interferon signaling complex]]
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Current revision

human IFNw-IFNAR ternary complex

PDB ID 3se4

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