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3eam
From Proteopedia
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| - | [[Image:3eam.png|left|200px]] | ||
| - | + | ==An open-pore structure of a bacterial pentameric ligand-gated ion channel== | |
| - | + | <StructureSection load='3eam' size='340' side='right'caption='[[3eam]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3eam]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eam OCA], [https://pdbe.org/3eam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eam RCSB], [https://www.ebi.ac.uk/pdbsum/3eam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eam ProSAT]</span></td></tr> |
| - | [[3eam]] | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eam_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eam ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | + | *[[Ion channels 3D structures|Ion channels 3D structures]] | |
| - | *[[Ion channels|Ion channels]] | + | == References == |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | < | + | </StructureSection> |
[[Category: Gloeobacter violaceus]] | [[Category: Gloeobacter violaceus]] | ||
| - | [[Category: Baaden | + | [[Category: Large Structures]] |
| - | [[Category: Bocquet | + | [[Category: Baaden M]] |
| - | [[Category: Changeux | + | [[Category: Bocquet N]] |
| - | [[Category: Corringer | + | [[Category: Changeux JP]] |
| - | [[Category: Delarue | + | [[Category: Corringer PJ]] |
| - | + | [[Category: Delarue M]] | |
| - | [[Category: Poupon | + | [[Category: Le Poupon C]] |
| - | [[Category: | + | [[Category: Nury H]] |
| - | + | ||
| - | + | ||
Current revision
An open-pore structure of a bacterial pentameric ligand-gated ion channel
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