3dvm

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[[Image:3dvm.png|left|200px]]
 
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{{STRUCTURE_3dvm| PDB=3dvm | SCENE= }}
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==Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex==
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<StructureSection load='3dvm' size='340' side='right'caption='[[3dvm]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3dvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DVM FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18940602}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dvm OCA], [https://pdbe.org/3dvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dvm RCSB], [https://www.ebi.ac.uk/pdbsum/3dvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dvm ProSAT]</span></td></tr>
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[[3dvm]] is a 2 chain structure of [[]], [[Calmodulin]] and [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVM OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/3dvm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dvm ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[|]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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*[[Calmodulin|Calmodulin]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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*[[Ion channels|Ion channels]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018940602</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Cooley, E S.]]
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[[Category: Cooley ES]]
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[[Category: Fujiwara, Y.]]
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[[Category: Fujiwara Y]]
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[[Category: Kim, E Y.]]
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[[Category: Kim EY]]
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[[Category: Minor, D L.]]
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[[Category: Minor DL]]
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[[Category: Petegem, F Van.]]
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[[Category: Rumpf CH]]
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[[Category: Rumpf, C H.]]
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[[Category: Van Petegem F]]
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[[Category: Calcium channel]]
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[[Category: Calcium-dependent]]
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[[Category: Calmodulin]]
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[[Category: Facilitation]]
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[[Category: Inactivation]]
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[[Category: Iq domain]]
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[[Category: Membrane protein]]
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[[Category: Voltage-gated]]
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Current revision

Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex

PDB ID 3dvm

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