4gee
From Proteopedia
(Difference between revisions)
m (Protected "4gee" [edit=sysop:move=sysop]) |
|||
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.== | |
| + | <StructureSection load='4gee' size='340' side='right'caption='[[4gee]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gee]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GEE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WT:(1R,5S,6S)-3-[5-CHLORO-6-ETHYL-2-(PYRIMIDIN-5-YLOXY)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL]-3-AZABICYCLO[3.1.0]HEXAN-6-AMINE'>0WT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gee OCA], [https://pdbe.org/4gee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gee RCSB], [https://www.ebi.ac.uk/pdbsum/4gee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gee ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GYRB_ENTFA GYRB_ENTFA] | ||
| - | + | ==See Also== | |
| - | + | *[[Gyrase 3D Structures|Gyrase 3D Structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Enterococcus faecalis V583]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bensen DC]] | ||
| + | [[Category: Chen Z]] | ||
| + | [[Category: Tari LW]] | ||
Current revision
Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
| |||||||||||
