3ucy

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[[Image:3ucy.jpg|left|200px]]
 
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{{STRUCTURE_3ucy| PDB=3ucy | SCENE= }}
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==Structure of Mg2+ bound N-terminal domain of calmodulin in the presence of Zn2+==
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<StructureSection load='3ucy' size='340' side='right'caption='[[3ucy]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ucy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UCY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ucy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ucy OCA], [https://pdbe.org/3ucy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ucy RCSB], [https://www.ebi.ac.uk/pdbsum/3ucy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ucy ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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===Structure of Mg2+ bound N-terminal domain of calmodulin in the presence of Zn2+===
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==See Also==
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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{{ABSTRACT_PUBMED_22803592}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3ucy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UCY OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:022803592</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Grabarek, Z.]]
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[[Category: Large Structures]]
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[[Category: Senguen, F T.]]
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[[Category: Grabarek Z]]
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[[Category: Calcium regulation]]
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[[Category: Senguen FT]]
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[[Category: Calcium-binding protein]]
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[[Category: Ef-hand]]
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[[Category: Metal binding]]
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Current revision

Structure of Mg2+ bound N-terminal domain of calmodulin in the presence of Zn2+

PDB ID 3ucy

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