3ucw

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[[Image:3ucw.jpg|left|200px]]
 
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{{STRUCTURE_3ucw| PDB=3ucw | SCENE= }}
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==Structure of MG2+ bound N-Terminal domain of Calmodulin==
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<StructureSection load='3ucw' size='340' side='right'caption='[[3ucw]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ucw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UCW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ucw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ucw OCA], [https://pdbe.org/3ucw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ucw RCSB], [https://www.ebi.ac.uk/pdbsum/3ucw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ucw ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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===Structure of MG2+ bound N-Terminal domain of Calmodulin===
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==See Also==
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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{{ABSTRACT_PUBMED_22803592}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3ucw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UCW OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:022803592</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Grabarek, Z.]]
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[[Category: Large Structures]]
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[[Category: Senguen, F T.]]
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[[Category: Grabarek Z]]
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[[Category: Calcium regulation]]
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[[Category: Senguen FT]]
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[[Category: Calcium-binding protein]]
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[[Category: Ef-hand]]
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[[Category: Metal binding]]
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Current revision

Structure of MG2+ bound N-Terminal domain of Calmodulin

PDB ID 3ucw

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