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4fww

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[[Image:4fww.jpg|left|200px]]
 
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{{STRUCTURE_4fww| PDB=4fww | SCENE= }}
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==Crystal structure of the Sema-PSI extracellular domains of human RON receptor tyrosine kinase==
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<StructureSection load='4fww' size='340' side='right'caption='[[4fww]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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===Crystal structure of the Sema-PSI extracellular domains of human RON receptor tyrosine kinase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fww]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FWW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[4fww]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWW OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fww OCA], [https://pdbe.org/4fww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fww RCSB], [https://www.ebi.ac.uk/pdbsum/4fww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fww ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RON_HUMAN RON_HUMAN] Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.<ref>PMID:7939629</ref> <ref>PMID:9764835</ref> <ref>PMID:18836480</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Large Structures]]
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[[Category: Chao, K L.]]
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[[Category: Chao KL]]
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[[Category: Herzberg, O.]]
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[[Category: Herzberg O]]
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[[Category: Beta-propeller]]
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[[Category: Cysteine-knot]]
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[[Category: Extracellular]]
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[[Category: Macrophage stimulating protein]]
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[[Category: N-glycosylation]]
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[[Category: Receptor tyrosine kinase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the Sema-PSI extracellular domains of human RON receptor tyrosine kinase

PDB ID 4fww

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