3va1

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[[Image:3va1.png|left|200px]]
 
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{{STRUCTURE_3va1| PDB=3va1 | SCENE= }}
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==Crystal structure of the mammalian MDC1 FHA domain==
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<StructureSection load='3va1' size='340' side='right'caption='[[3va1]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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===Crystal structure of the mammalian MDC1 FHA domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3va1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VA1 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22211259}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3va1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3va1 OCA], [https://pdbe.org/3va1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3va1 RCSB], [https://www.ebi.ac.uk/pdbsum/3va1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3va1 ProSAT]</span></td></tr>
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[[3va1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VA1 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/MDC1_MOUSE MDC1_MOUSE] Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (By similarity).
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<ref group="xtra">PMID:022211259</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Huang, K F.]]
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[[Category: Huang KF]]
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[[Category: Kao, Y Y.]]
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[[Category: Kao YY]]
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[[Category: Tsai, M D.]]
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[[Category: Tsai MD]]
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[[Category: Wu, H H.]]
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[[Category: Wu HH]]
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[[Category: Wu, P Y.]]
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[[Category: Wu PY]]
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[[Category: Cell cycle]]
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[[Category: Dna-damage]]
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[[Category: Fha domain]]
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[[Category: Mdc1 dimerization]]
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Current revision

Crystal structure of the mammalian MDC1 FHA domain

PDB ID 3va1

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OCA

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