3qi2

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[[Image:3qi2.png|left|200px]]
 
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{{STRUCTURE_3qi2| PDB=3qi2 | SCENE= }}
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==A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco==
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<StructureSection load='3qi2' size='340' side='right'caption='[[3qi2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qi2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QI2 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22383884}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.797&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qi2 OCA], [https://pdbe.org/3qi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qi2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qi2 ProSAT]</span></td></tr>
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[[3qi2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI2 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
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<ref group="xtra">PMID:022383884</ref><ref group="xtra">PMID:017603074</ref><ref group="xtra">PMID:011976690</ref><references group="xtra"/>
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== References ==
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[[Category: Heterotrimeric G-protein GTPase]]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bosch, D E.]]
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[[Category: Large Structures]]
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[[Category: Kimple, A J.]]
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[[Category: Bosch DE]]
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[[Category: Miley, M J.]]
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[[Category: Kimple AJ]]
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[[Category: Siderovski, D P.]]
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[[Category: Miley MJ]]
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[[Category: Willard, F S.]]
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[[Category: Siderovski DP]]
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[[Category: Adp-ribosylation]]
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[[Category: Willard FS]]
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[[Category: All-helical domain]]
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[[Category: Arginine finger]]
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[[Category: Goloco motif]]
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[[Category: Gtp binding]]
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[[Category: Guanine nucleotide dissociation inhibitor]]
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[[Category: Lipoprotein]]
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[[Category: Nucleotide binding]]
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[[Category: Ras-like domain]]
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[[Category: Rgs14 goloco]]
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[[Category: Signaling protein]]
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[[Category: Transducer]]
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Current revision

A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco

PDB ID 3qi2

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