This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3uwo
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:3uwo.png|left|200px]] | ||
| - | + | ==Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation== | |
| + | <StructureSection load='3uwo' size='340' side='right'caption='[[3uwo]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3uwo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UWO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DJ:3-(1-METHYL-2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)BENZAMIDE'>0DJ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwo OCA], [https://pdbe.org/3uwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uwo RCSB], [https://www.ebi.ac.uk/pdbsum/3uwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KTHY_PSEAE KTHY_PSEAE] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity). | ||
| - | == | + | ==See Also== |
| - | + | *[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[ | + | [[Category: Pseudomonas aeruginosa PAO1]] |
| - | + | [[Category: Chang J]] | |
| - | + | [[Category: Choi JY]] | |
| - | + | [[Category: Desbonnet CR]] | |
| - | [[Category: | + | [[Category: Dillman K]] |
| - | [[Category: | + | [[Category: Miller AA]] |
| - | [[Category: Chang | + | [[Category: Miller JR]] |
| - | [[Category: Choi | + | [[Category: Plummer MS]] |
| - | [[Category: Desbonnet | + | [[Category: Roush WR]] |
| - | [[Category: Dillman | + | [[Category: Soutter HH]] |
| - | [[Category: Miller | + | [[Category: Starr J]] |
| - | [[Category: Miller | + | |
| - | [[Category: Plummer | + | |
| - | [[Category: Roush | + | |
| - | [[Category: Soutter | + | |
| - | [[Category: Starr | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation
| |||||||||||
