1id1

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[[Image:1id1.jpg|left|200px]]<br /><applet load="1id1" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1id1, resolution 2.4&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL==
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The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K+ transporters and K+ channels. The RCK domain has a Rossmann-fold topology with unique positions, not commonly conserved among Rossmann-fold proteins, composing a well-conserved salt bridge and a hydrophobic dimer interface. Structure-based amino acid sequence alignments and mutational analysis are used to demonstrate that an RCK domain is also present and is an important component of the gating machinery in eukaryotic large-conductance Ca2+ activated K+ channels.
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<StructureSection load='1id1' size='340' side='right'caption='[[1id1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1id1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ID1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ID1 FirstGlance]. <br>
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1ID1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ID1 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1id1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1id1 OCA], [https://pdbe.org/1id1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1id1 RCSB], [https://www.ebi.ac.uk/pdbsum/1id1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1id1 ProSAT]</span></td></tr>
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==Reference==
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</table>
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Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel., Jiang Y, Pico A, Cadene M, Chait BT, MacKinnon R, Neuron. 2001 Mar;29(3):593-601. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11301020 11301020]
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== Function ==
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[https://www.uniprot.org/uniprot/KCH_ECOLI KCH_ECOLI] K(+)-specific ion channel. May play a role in the defense against osmotic shock.<ref>PMID:8170937</ref> <ref>PMID:12912904</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/1id1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1id1 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cadene, M.]]
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[[Category: Cadene M]]
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[[Category: Chait, B T.]]
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[[Category: Chait BT]]
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[[Category: Jiang, Y.]]
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[[Category: Jiang Y]]
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[[Category: MacKinnon, R.]]
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[[Category: MacKinnon R]]
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[[Category: Pico, A.]]
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[[Category: Pico A]]
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[[Category: bk channel]]
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[[Category: e coli potassium channel]]
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[[Category: rck domain]]
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[[Category: rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:36 2008''
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Current revision

CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL

PDB ID 1id1

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