2jm3

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[[Image:2jm3.png|left|200px]]
 
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{{STRUCTURE_2jm3| PDB=2jm3 | SCENE= }}
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==Solution structure of the THAP domain from C. elegans C-terminal binding protein (CtBP)==
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<StructureSection load='2jm3' size='340' side='right'caption='[[2jm3]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jm3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JM3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm3 OCA], [https://pdbe.org/2jm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jm3 RCSB], [https://www.ebi.ac.uk/pdbsum/2jm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CTBP1_CAEEL CTBP1_CAEEL] Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism.<ref>PMID:18005989</ref> <ref>PMID:19164523</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The THAP (Thanatos-associated protein) domain is a recently discovered zinc-binding domain found in proteins involved in transcriptional regulation, cell-cycle control, apoptosis and chromatin modification. It contains a single zinc atom ligated by cysteine and histidine residues within a Cys-X(2-4)-Cys-X(35-53)-Cys-X(2)-His consensus. We have determined the NMR solution structure of the THAP domain from Caenorhabditis elegans C-terminal binding protein (CtBP) and show that it adopts a fold containing a treble clef motif, bearing similarity to the zinc finger-associated domain (ZAD) from Drosophila Grauzone. The CtBP THAP domain contains a large, positively charged surface patch and we demonstrate that this domain can bind to double-stranded DNA in an electrophoretic mobility-shift assay. These data, together with existing reports, indicate that THAP domains might exhibit a functional diversity similar to that observed for classical and GATA-type zinc fingers.
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===Solution structure of the THAP domain from C. elegans C-terminal binding protein (CtBP)===
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Solution structure of the THAP domain from Caenorhabditis elegans C-terminal binding protein (CtBP).,Liew CK, Crossley M, Mackay JP, Nicholas HR J Mol Biol. 2007 Feb 16;366(2):382-90. Epub 2006 Nov 18. PMID:17174978<ref>PMID:17174978</ref>
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{{ABSTRACT_PUBMED_17174978}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2jm3" style="background-color:#fffaf0;"></div>
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[[2jm3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM3 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:017174978</ref><references group="xtra"/>
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Crossley, M.]]
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[[Category: Large Structures]]
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[[Category: Liew, C K.]]
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[[Category: Crossley M]]
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[[Category: Mackay, J P.]]
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[[Category: Liew CK]]
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[[Category: Nicholas, H R.]]
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[[Category: Mackay JP]]
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[[Category: Metal binding protein]]
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[[Category: Nicholas HR]]
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[[Category: Protein]]
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[[Category: Zinc finger]]
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Current revision

Solution structure of the THAP domain from C. elegans C-terminal binding protein (CtBP)

PDB ID 2jm3

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