1pnn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:01, 15 November 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1pnn.png|left|200px]]
 
-
{{STRUCTURE_1pnn| PDB=1pnn | SCENE= }}
+
==PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA==
 +
<StructureSection load='1pnn' size='340' side='right'caption='[[1pnn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1pnn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PNN FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=IPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-5-IODOURACIL'>IPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pnn OCA], [https://pdbe.org/1pnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pnn RCSB], [https://www.ebi.ac.uk/pdbsum/1pnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pnn ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The crystal structure of a nucleic acid triplex reveals a helix, designated P-form, that differs from previously reported nucleic acid structures. The triplex consists of one polypurine DNA strand complexed to a polypyrimidine hairpin peptide nucleic acid (PNA) and was successfully designed to promote Watson-Crick and Hoogsteen base pairing. The P-form helix is underwound, with a base tilt similar to B-form DNA. The bases are displaced from the helix axis even more than in A-form DNA. Hydrogen bonds between the DNA backbone and the Hoogsteen PNA backbone explain the observation that polypyrimidine PNA sequences form highly stable 2:1 PNA-DNA complexes. This structure expands the number of known stable helical forms that nucleic acids can adopt.
-
===PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA===
+
A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex.,Betts L, Josey JA, Veal JM, Jordan SR Science. 1995 Dec 15;270(5243):1838-41. PMID:8525381<ref>PMID:8525381</ref>
-
{{ABSTRACT_PUBMED_8525381}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1pnn" style="background-color:#fffaf0;"></div>
-
[[1pnn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PNN OCA].
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:008525381</ref><references group="xtra"/>
+
</StructureSection>
-
[[Category: Betts, L.]]
+
[[Category: Large Structures]]
-
[[Category: Veal, J M.]]
+
[[Category: Betts L]]
-
[[Category: Hairpin pna:dna triplex]]
+
[[Category: Veal JM]]
-
[[Category: Peptide nucleic acid-dna complex]]
+
-
[[Category: Triplex watson-crick hoogsteen]]
+

Current revision

PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA

PDB ID 1pnn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pnn"
Personal tools